Radiation therapy remains as one of the main cancer treatment modalities. Typical regimens for radiotherapy comprise a constant dose administered on weekdays, and no radiation on weekends. In this paper, we examine adaptive dosages of radiation treatment strategies for heterogeneous tumors using a dynamical system model that consist of radiation-resistant and parental populations with unique interactive properties, namely, PC3 and DU145 prostate cancer cell lines. We show that stronger doses of radiation given in longer time intervals, while keeping the overall dosage the same, are effective in PC3 cell lines, but not in DU145 cell lines. In addition, we tested an adaptive dosing schedule by administering a stronger dosage on Friday to compensate for the treatment-off period during the weekend, which was effective in decreasing the final tumor volume of both cell lines. This result creates interesting possibilities for new radiotherapy strategies at clinics that cannot provide treatment on weekends.
Alvarez, Jose; Storey, Kathleen M.; Kannan, Pavitra; and Cho, Heyrim
"Effective Dose Fractionation Schemes of Radiotherapy for Prostate Cancer,"
Spora: A Journal of Biomathematics: Vol. 8, 16–30.
Available at: https://ir.library.illinoisstate.edu/spora/vol8/iss1/4