Date of Award
Doctor of Philosophy (PhD)
School of Biological Sciences
Maintaining genomic integrity is critical to avoid sequence mutations and genetic disease. However the immune system requires genomic rearrangements in order to produce novel antibodies and illicit a full immunological response. The expression of DNA modifying enzymes is essential for antibody production but the off target effects are not well understood. The work presented here was performed to elucidate molecular mechanisms responsible for the regulation and targeting of DNA editing enzymes, as well as characterize repair of these lesions at off target loci.
Holton, Nate Warren, "Genomic Deoxyuracil: Targeting, Regulation and Repair" (2015). Theses and Dissertations. 468.