Graduation Term
9-25-2015
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
School of Biological Sciences
Committee Chair
Erik Larson
Abstract
Maintaining genomic integrity is critical to avoid sequence mutations and genetic disease. However the immune system requires genomic rearrangements in order to produce novel antibodies and illicit a full immunological response. The expression of DNA modifying enzymes is essential for antibody production but the off target effects are not well understood. The work presented here was performed to elucidate molecular mechanisms responsible for the regulation and targeting of DNA editing enzymes, as well as characterize repair of these lesions at off target loci.
Recommended Citation
Holton, Nate Warren, "Genomic Deoxyuracil: Targeting, Regulation and Repair" (2015). Theses and Dissertations. 468.
https://ir.library.illinoisstate.edu/etd/468
DOI
http://doi.org/10.30707/ETD2015.Holton.N
Page Count
138