Polyoxidovanadates' interactions with proteins: An overview

Authors

Manuel Aureliano, Universidade do AlgarveFollow
Nadiia I. Gumerova, Universitat Wien
Giuseppe Sciortino, Barcelona Institute of Science and Technology
Eugenio Garribba, Universita di Sassari
Craig C. McLauchlan, Illinois State UniversityFollow
Annette Rompel, Universitat WienFollow
Debbie C. Crans, Colorado State UniversityFollow

Document Type

Article

Publication Date

3-1-2022

Keywords

Polyoxidometalates, Polyoxidovanadates, Decavanadate, Vanadate, Enzymes, Proteins

Abstract

Polyoxidovanadates (POVs, previously named polyoxovanadates) are a subgroup of polyoxidometalates (POMs, previously named polyoxometalates) with interesting pharmacological actions that have been tested as potential antidiabetic, antibacterial, antiprotozoal, antiviral, and anticancer drugs. They contain mainly vanadium and are able to interact with proteins, affecting various biological processes. The most studied POV is the isopolyoxidovanadate decavanadate (V10), which interacts with proteins and/or enzymes such as tyrosine protein phosphatases, P-type ATPases, RNA triphosphatases, myosin and actin. However, in many POVs–protein systems, the binding sites and/or the residues involved in the interaction are not identified. In the present review, the interactions of POVs, as well as linear trivanadate (V3), both linear and cyclic tetravanadate (V4) and two proposed heptavanadate (V7; which are better described by V10 molecules), with proteins are described through X-ray crystallographic studies. Interactions with POVs through theoretical and spectroscopic studies of proteins related to muscle contraction, serum, oxidative stress, and diabetes were also discussed. In sum, herein, we describe POVs’ interactions with various proteins including acid phosphatase A, receptor tyrosine kinase, ecto-nucleoside triphosphate diphosphohydrolase (NTPDases), transient receptor potential cation channel (TRPM4), phosphoglucomutases, P-type ATPases, myosin, actin, transferrin, albumin, and glucosidases, among others. The putative POVs’ effects on proteins are impacted by the POV' stability and speciation. The modes of POVs' interactions include H-bond, electrostatic, H-bond + electrostatic, van der Waals, and covalent binding. The spectroscopic, X-ray and computational results, the sites and modes of binding are described in detail.

Comments

This article was originally published in Coordination Chemistry Reviews 454, no. 1 (March 2022), 214344, https://doi.org/10.1016/j.ccr.2021.214344.

Recommended Citation

Aureliano, Manuel; Gumerova, Nadiia I.; Sciortino, Giuseppe; Garribba, Eugenio; McLauchlan, Craig C.; Rompel, Annette; and Crans, Debbie C., "Polyoxidovanadates' interactions with proteins: An overview" (2022). Faculty Publications – Chemistry. 7.
https://ir.library.illinoisstate.edu/fpchem/7