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Steven J. Peters

Mentor Department



Substituted 1,2,3-triazoles have displayed use as effective agents in numerous pharmaceuticals. Specifically, compounds containing substituents at the N1 and N2 position have shown promise as antifungal and anticancer agents.1The medicinal potential of these compounds can be derived from their structural stability, polarity, and ability to hydrogen bond to macromolecules. The unique π-framework of these triazole tautomers has drawn interest to the electronic and structural properties of these triazole systems, primarily the varying aromatic character of the N3-moiety and its influence on the stability of the system. Studies have shown the differences in aromaticity between the two tautomers varies depending on their environment, and our research group has developed an interest in studying these systems upon the addition of a single electron.2Using electron paramagnetic resonance (EPR) spectroscopic methods, we have been able to study the relative electron affinity of these tautomers, hence generating a greater understanding of the relative stability of these systems and their anion radical counterparts.

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