This dissertation is accessible only to the Illinois State University community.
- Off-Campus ISU Users: To download this item, click the "Off-Campus Download" button below. You will be prompted to log in with your ISU ULID and password.
- Non-ISU Users: Contact your library to request this item through interlibrary loan.
Graduation Term
2018
Degree Name
Master of Science (MS)
Department
School of Biological Sciences
Committee Chair
Alysia Vrailas-Mortimer
Abstract
Aging is a process that affects all organisms. Despite this, little is known about the underlying molecular mechanisms of aging. Previously, our lab has established p38b MAPK (p38Kb) as a model for aging in Drosophila Melanogaster. Here, we identify lamin as a downstream target of p38Kb and Chaperone Assisted-Selective Autophagy (CASA). lamin, when mutated, leads to protein aggregation and results in diseases that affect aging and muscle function. We also are in the process of identifying other downstream targets of p38Kb with changes in age and levels of oxidative stress.
Access Type
Thesis-ISU Access Only
Recommended Citation
Almassey, Michael James, "Identification of Age-Related Downstream Targets of P38 B Mapk" (2018). Theses and Dissertations. 1019.
https://ir.library.illinoisstate.edu/etd/1019
DOI
http://doi.org/10.30707/ETD2019.Almassey.M