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Date of Award
10-18-2018
Document Type
Thesis-ISU Access Only
Degree Name
Master of Science (MS)
Department
School of Biological Sciences
First Advisor
Alysia Vrailas-Mortimer
Abstract
Aging is a process that affects all organisms. Despite this, little is known about the underlying molecular mechanisms of aging. Previously, our lab has established p38b MAPK (p38Kb) as a model for aging in Drosophila Melanogaster. Here, we identify lamin as a downstream target of p38Kb and Chaperone Assisted-Selective Autophagy (CASA). lamin, when mutated, leads to protein aggregation and results in diseases that affect aging and muscle function. We also are in the process of identifying other downstream targets of p38Kb with changes in age and levels of oxidative stress.
Recommended Citation
Almassey, Michael James, "Identification of Age-Related Downstream Targets of P38 B Mapk" (2018). Theses and Dissertations. 1019.
https://ir.library.illinoisstate.edu/etd/1019
DOI
http://doi.org/10.30707/ETD2019.Almassey.M
Page Count
58
Comments
Imported from ProQuest Almassey_ilstu_0092N_11330.pdf