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Date of Award

10-18-2018

Document Type

Thesis and Dissertation-ISU Access Only

Degree Name

Master of Science (MS)

Department

School of Biological Sciences

First Advisor

Alysia Vrailas-Mortimer

Abstract

Aging is a process that affects all organisms. Despite this, little is known about the underlying molecular mechanisms of aging. Previously, our lab has established p38b MAPK (p38Kb) as a model for aging in Drosophila Melanogaster. Here, we identify lamin as a downstream target of p38Kb and Chaperone Assisted-Selective Autophagy (CASA). lamin, when mutated, leads to protein aggregation and results in diseases that affect aging and muscle function. We also are in the process of identifying other downstream targets of p38Kb with changes in age and levels of oxidative stress.

Comments

Imported from ProQuest Almassey_ilstu_0092N_11330.pdf

DOI

http://doi.org/10.30707/ETD2019.Almassey.M

Page Count

58

Available for download on Friday, February 05, 2021

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