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Graduation Term


Document Type

Thesis-ISU Access Only

Degree Name

Master of Science (MS)


School of Biological Sciences

Committee Chair

Alysia Vrailas-Mortimer


Aging is a process that affects all organisms. Despite this, little is known about the underlying molecular mechanisms of aging. Previously, our lab has established p38b MAPK (p38Kb) as a model for aging in Drosophila Melanogaster. Here, we identify lamin as a downstream target of p38Kb and Chaperone Assisted-Selective Autophagy (CASA). lamin, when mutated, leads to protein aggregation and results in diseases that affect aging and muscle function. We also are in the process of identifying other downstream targets of p38Kb with changes in age and levels of oxidative stress.


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