This dissertation is accessible only to the Illinois State University community.
- Off-Campus ISU Users: To download this item, click the "Off-Campus Download" button below. You will be prompted to log in with your ISU ULID and password.
- Non-ISU Users: Contact your library to request this item through interlibrary loan.
Graduation Term
2016
Degree Name
Master of Science (MS)
Department
School of Biological Sciences
Committee Chair
Radheshyam K. Jayaswal
Abstract
This study explored the role Staphylococcus aureus autolysins play in biofilm formation, pathogenesis and resistance to both cell wall targeting and protein synthesis-inhibiting antibiotics. Using a variety of mutant strains in the USA300 background lacking genes encoding autolysins, sortases, histidine-kinase signaling systems, as well as regulatory proteins, the role of these genes in MRSA could be elucidated. The results suggest a variety of negative phenotypes that correlate with the loss of these key autolysins and regulatory genes. Decreases in biofilm formation, antibiotic resistance, and pathogenesis were seen in many of the mutants. This indicates a possible relationship between autolysins and many of the characteristics of pathogenesis in Staphylococcus aureus.
Access Type
Thesis-ISU Access Only
Recommended Citation
McFadden, Samuel August, "Role of Autolysins in Biofilm Formation, Pathogenesis and Antibiotic Resistance in Staphylococcus Aureus" (2016). Theses and Dissertations. 529.
https://ir.library.illinoisstate.edu/etd/529
DOI
http://doi.org/10.30707/ETD2016.McFadden.S